Literature review on asthma
They observed that rage and tlr2 expression on the cd11b−cd11c+ cells (dendritic cells) augmented importantly in asthmatic animals compared with control ones and these changes were incredibly attenuated by the injection of hmgb1 neutralizing antibodies . Caregivers may also be less likely to engage in recommended preventive measures to successfully manage their children’s asthma and minimize their children’s symptoms, e.
These studies clearly suggest that the extent to which chronic health conditions, such as asthma, may increase the risk of child maltreatment experiences needs to be investigated more endations for future on existing research on the impact of child maltreatment on pediatric asthma, there are several recommendations for future research. The authors hypothesize that an approach using technology based delivery methods to provide age-appropriate education, which promotes self-regulation and includes psychosocial elements, could help children with asthma decrease exacerbations in the short term and establish healthy habits in the long term.
If maltreatment reduces the availability of glucocorticoids in the airways, or decreases cellular sensitivity to these molecules, there could be implications for asthma expression and/or management [73, 74]. In 2015, using a tdi-induced murine asthma model, demonstrated that caspase-1 activation and hmgb1 production was mediated by phosphatidylinositol 3-kinases (pi3ks); this study also assessed the role of ly294002 a specific inhibitor of pi3k.
Future research should focus on understanding how child maltreatment contributes to asthma disease risk and progression in this highly vulnerable oundasthma remains one of the most prevalent chronic health problems facing american youth today. Paediatrnurs 14: la, kockritz jl, ludke rl, bernstein ja (2012) enhancing school-based asthma education efforts using computer-based education for children.
Bronchial hyperresponsiveness and the development of asthma and copd in asymptomatic individuals: sapaldia cohort study. In short, a more detailed examination of potential moderators and mediators of the association between child maltreatment and asthma is needed.
American thoracic society (ats), in their guidelines of 1995 (1) defined asthma, chronic bronchitis, emphysema, copd, airflow obstruction and identified 11 distinct syndromes. Online j public health inform 5: le k, car m, morrison c, car j (2012) apps for asthma self-management: a systematic assessment of content and tools.
Hmgb1 levels in induced sputum were higher in patients with all severities of asthma and in those with copd than healthy subjects. The literature is lacking in studies addressing the creation of education material for children, especially those that include information about self-regulating e research suggesting children engaged in health education have decreased morbidity and increased self-efficacy, doctors give little attention to educating young children [20,23].
An estimated 14 % of children and adolescents under the age of 18 are diagnosed with asthma at some point in their lives . Evaluated children who used a program entitled asthma command and reported asthma knowledge and medical selfmanagement behaviors increased in children enrolled in the program .
Bronchostenosis mechanism, fundamental in the asthmatic disease, could be sustained and modulated by this alarmin. J pediatr health care 17: r ek, cook g, marti cn, gomes m, meeder l (2015) effectiveness of a school-based academic asthma health education and counseling program on fostering acceptance of asthma in older school-age students with asthma.
For this reason, young children with asthma need to be taught self-regulation, which refers to how an individual systematically manages feelings, thoughts, and behaviors,  adjusting them to meet a situation’s demands . Ionian@ractaims: this paper reports a review conducted to identify the factors in the indoor environment that have an evidence-based link with the exacerbation or development of asthma and to identify measures that healthcare professionals can promote to reduce exposure to these risk factors in the ound: the indoor environment, particularly at home, has been recognized as a major source of exposure to allergens and toxic chemicals.
J am med inform assoc 8: th, hauenstein ej (2008) pilot testing okay with asthma: an online asthma intervention for school-age children. Emerged from this literature review was the confirmation of hmgb-1 involvement in diseases characterised by chronic inflammation, especially in pulmonary pathologies.
This may also provide insights into potential protective factors which could inform future research and prevention , more work is needed to understand the biological pathways that might connect child maltreatment with asthma outcomes. These findings are further strengthened by reports of interventions designed to reduce allergen burdens inside the homes of youth with asthma resulting in improved clinical outcomes among these youth .
8), in another review (8) prefer the following major criteria for acos: a physician diagnosis of asthma and copd in the same patient, history or evidence of atopy, for example, hay fever, elevated total ige, age 40 years or more, smoking >10 pack-years, postbronchodilator fev1 <80% predicted and fev1/fvc <70%. The dominance of th2 response is characteristic of allergic eosinophilic asthma, t2 response characteristic of non allergic eosinophilic asthma, and t17 of neutrophilic asthma.
Were the first to test the level of hmgb1 and of the endogenous secretory receptor for advanced glycation end products (esrage) in sputum of asthmatic patient. Parents of children with maltreatment histories are also more likely to be struggling with mental health and substance abuse problems themselves [47–49], both of which may further signal an inability on the part of parents to be actively involved in their children’s disease management ’s own behaviors may also contribute to worse asthma outcomes.
Psychol health 28: s, baggott c, gibson f, mobbs s, taylor rm (2015) a critical review of the use of technology to provide psychosocial support for children and young people with long-term conditions. There were no significant variation in sputum hmgb1 levels between subjects with mild asthma and controls and between mild asthma and moderate asthma.