Literature review on malaria

Interventions to prevent malaria include intermittent preventive treatment, insecticide-treated nets, and case management of malaria infection and : 18455095 doi: 10. British medical d, liberati a, tetzlaff j, altman dg, the prisma group (2009) preferred reporting items for systematic reviews and meta-analyses: the prisma statement. The pathogenesis of the disease may be mediated by these same host-derived biologically active molecules, perhaps elicited by putative malarial toxins released from the infected erythrocytes (clark et al 2000, playfair et al 1996 and schofield et al 2002).

Ript ript raduate research e ture review: insights into formulating a protective malarial :  padhmanand sudhakar and prasanth ution:  's engineering college, anna university date:  january a, unlike many diseases, has evolved as a result of millions of years of interactions at various levels with the mammalian system and hence has found ways to gather resistance to drugs and insensitivity to other treatment modalities. These developments further justify the cause and urgency for formulating an effective vaccine against y requirements of malarial vaccines:From experience, it is learnt that different populations demand different types of malarial vaccines making use of the different arms of the natural immune response system (figure 3). The quantity may reflect scientific research activity but the initial primary impact is contribution to policy dsmalaria researchfundinghealth oundresearch is defined as an organized curiosity leading to a systematic enquiry, with the purpose of understanding the subject at hand and generating new knowledge.

In our review, we would like to outline the recent multidimensional efforts aimed at adopting suitable methods by which natural immunity like responses can be generated by a malarial vaccine. Search published studies the resulting titles and abstracts were reviewed independently by two authors (tv and kb) to select papers or reports to read in full text. Use cookies to improve your experience with our information about our cookie through the plos taxonomy to find articles in your more information about plos subject areas, patients with malaria-like symptoms seek treatment in private medicine retail outlets (pmr) that distribute malaria medicines but do not traditionally provide diagnostic services, potentially leading to overtreatment with antimalarial drugs.

After full-text review of each study, the sample size was 36 studies, which also included the eligibility phase. Malarial infection comes with biggest problem that it has a strong possibility of reactivation following a temporal period of relapse. Anxiety over the potential for patients to worsen without being given antimalarials seems paramount [40, 41], just as with antibiotics in other settings [42].

Modern vaccines rely on the fact that if natural immunity could be mimicked, then vaccination would prevent severe malaria and malaria-related deaths. The basic purpose of a vaccine is to reduce the incidence of severe malaria, and malaria-associated mortality in infants and children with heavy exposure to plasmodium falciparum, such as those living in sub-saharan africa. Effectiveness of provider and community interventions to improve treatment of uncomplicated malaria in nigeria: a cluster randomized controlled trial.

However, with growing research demand, comrec, under the college of medicine (com) in the university of malawi, was established in 1996 and mandated to facilitate the review of proposals of faculty members and students of com and kamuzu college of nursing, and their affiliates which include the malawi-liverpool wellcome (mlw) trust, blantyre malaria project (bmp), malaria alert centre (mac), and centre for reproductive health (crh). The beliefs and cultural practices of patients are largely related to the success of a malaria control program (pmi, n. First, evidence is needed on how to integrate malaria testing into case management beyond malaria.

The use of sulphadoxinepyrimethamine is related to malaria programs that target pregnant women, since a fetus can contract malaria if the mother is infected. Qualitative studies considered cultural practices and their possible influence on malaria prevention and 2: distribution of studies by identification of cultural practices in zanzibar can be of value, because in other countries, such as ghana and kenya, some cultural practices reduce the impact of malaria programs [25,26]. Reported that the continued persistence of malaria in africa appears to be largely due to socio-cultural factors, which are often at variance with standard control methods.

Would rational use of antibiotics be compromised in the era of test-based management of malaria? Irs = indoor residual spraying; itn = insecticide treated nets; long-lasting insecticidal treated nets (llin); act = artemisinin combination therapy; aq = amodiaquine; asaq = artesunate-amodiaquine*barriers or consequences were not explicitly stated in the 2: matrix of malaria topics and intervention activities in al barriers: although no cultural barriers were identified for zanzibar, other studies in sub-saharan africa do describe such barriers. Malaria research from malawi was mainly published in international journals since only three african journal were identified in this study and these included the african journal of health sciences, african health sciences, and the malawi medical journal.

Thus it’s important to first review what’s known about how the body’s immune system responds to the malaria parasite and why the body has such trouble clearing knowledge is needed to guide a potentially successful strategy for developing a vaccine. The medline/pubmed, an online international database, was chosen as the only database searched because it freely provides access to over 5000 peer reviewed indexed journals which are periodically updated by the us national library of medicine and hence it is bound to capture a large number of viable research publications [10, 11]. This study aimed to assess the type and amount of malaria research conducted in malawi from 1984 to 2016 and its related source of funding.

The research focus of these institutions is reflected in the findings of this review, as clinical and basic research dominate in the fields of malaria in pregnancy, severe malaria and vector and/or agent dynamics. Aim of this study was to assess the malaria research output by mapping the type and amount of malaria research conducted in malawi since 1984 when the first nmcp was established to 2016 when this study was conducted. Thus the general idea is to block transmission along with eliciting protection against the ideal malaria vaccine would prevent all infection by priming the immune system to destroy all parasites, whether free swimming in the blood, while in the liver, or even, theoretically, while in red blood cells.